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A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom J. Venom. Anim. Toxins incl. Trop. Dis.
Barbosa,Alexandre Naime; Boyer,Leslie; Chippaux,Jean-Philippe; Medolago,Natalia Bronzatto; Caramori,Carlos Antonio; Paixão,Ariane Gomes; Poli,João Paulo Vasconcelos; Mendes,Mônica Bannwart; Santos,Lucilene Delazari dos; Ferreira Jr,Rui Seabra; Barraviera,Benedito.
Abstract Background Envenomation caused by multiple stings from Africanized honeybees Apis mellifera constitutes a public health problem in the Americas. In 2015, the Brazilian Ministry of Health reported 13,597 accidents (incidence of seven cases per 100,000 inhabitants) with 39 deaths (lethality of 0.25%). The toxins present in the venom, which include melittin and phospholipase A2, cause lesions in diverse organs and systems that may be fatal. As there has been no specific treatment to date, management has been symptomatic and supportive only. Methods In order to evaluate the safety and neutralizing capacity of a new apilic antivenom, as well as to confirm its lowest effective dose, a clinical protocol was developed to be applied in a multicenter,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apis mellifera; Bee venom; Toxins; Envenomation; Heterologous serum; Apilic antivenom; Bee antivenom.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100309
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Antivenom reversal of biochemical alterations induced by black scorpion Heterometrus fastigiousus Couzijn venom in mice J. Venom. Anim. Toxins incl. Trop. Dis.
Chaubey,MK.
In the present study, Heterometrus fastigiousus venom (HFV) was employed as antigen to produce species-specific scorpion antivenom (SAV) in albino mice (NIH) strain. To determine SAV efficacy, it was pre-incubated with 10 LD50 of HFV and then injected subcutaneously into mice. Subsequently, mortality was observed after 24 hours. Minimum effective dose (MED) was 12.5 LD50 of HFV/mL of SAV. SAV effectiveness to reverse HFV-induced biochemical alterations in mice was analyzed by challenge method. Simultaneously, mice received subcutaneously 40% of 24-hour-LD50 of HFV and intravenously SAV. After four hours, changes in serum glucose, free amino acids, uric acids, pyruvic acid, cholesterol, total protein, alkaline phosphatase, acid phosphatase, lactic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Antivenom; Envenomation; Heterometrus fastigiousus; Serotherapy.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200006
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Contribution of ultrasonography to the diagnosis of internal bleeding in snakebite envenomation J. Venom. Anim. Toxins incl. Trop. Dis.
Tchaou,Blaise Adelin; Tové,Kofi-Mensa Savi de; Tové,Yolande Sissinto-Savi de; Djomga,Aurélien Tchémaha C.; Aguemon,Abdou-Rahman; Massougbodji,Achille; Chippaux,Jean-Philippe.
Abstract Background In Africa, snakebite envenomations are frequently complicated by life-threatening hemorrhagic syndromes. The authors of the present study conducted a prospective analysis at the University Hospital of Parakou (north of Benin) for seven months (January 1 to July 31, 2014) to assess the contribution of ultrasonography to the diagnosis of internal bleedings and management of envenomation. Methods An ultrasound examination was performed in all patients with clinical envenomation regardless of its severity. The study involved 32 patients admitted to the ICU of the University Hospital of Parakou. Results The average age was 27 ± 13.9 years. The main signs of severity were: prolongation of clotting time (88 %), severe anemia (41 %),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Envenomation; Ultrasound; Internal bleeding; Hemoperitoneum; Hematoma.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100306
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Deinagkistrodon acutus envenomation: a report of three cases J. Venom. Anim. Toxins incl. Trop. Dis.
Cheng,Chin-Lung; Mao,Yan-Chiao; Liu,Po-Yu; Chiang,Liao-Chun; Liao,Shu-Chen; Yang,Chen-Chang.
Abstract Background Deinagkistrodon acutus envenomation is associated with severe hematological and wound complications but is rarely described. Case presentation Herein, we report three cases of victims bitten by D. acutus and indicate that rapid-onset severe coagulopathy and thrombocytopenia are distinct features of D. acutus snakebite, which are not observed in other crotaline snakebites (i.e., Trimeresurus stejnegeri and Protobothrops mucrosquamatus) in Taiwan. The toxic effects could occur as early as 2 to 3 h following D. acutus envenomation and persist if the administration of specific antivenom is delayed or even not commenced. Based on our findings, 2 to 4 vials of specific antivenom as the first dose should be administered to victims and...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Coagulopathy; Thrombocytopenia; Envenomation; Deinagkistrodon acutus; Snakebite.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100504
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Delayed double reading of whole blood clotting test (WBCT) results at 20 and 30 minutes enhances diagnosis and treatment of viper evenomation J. Venom. Anim. Toxins incl. Trop. Dis.
Benjamin,Jordan Max; Chippaux,Jean-Philippe; Sambo,Bio Tamou; Massougbodji,Achille.
Abstract Background The whole blood clotting test (WBCT) is a simple test of coagulation that is often used in the assessment, diagnosis, and therapeutic monitoring of snakebite patients in sub-Saharan Africa. WBCT requires only a clean glass tube and several milliliters of venous blood and is ideal for use in poorly equipped health centers throughout the rural areas where 95% of snakebites occur. However, questions surrounding the accuracy and reliability of the test remain unanswered due to variations in testing conditions and a lack of comparative research with which to validate them. This is the first study to evaluate WBCT results at both 20-min (WBCT20) and 30-min (WBCT30) reading times in the same group of snakebite patients. Methods In order to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Africa; Snakebite; Echis; Envenomation; Whole blood clotting test; WBCT; Venom-induced consumption coagulopathy; Carpet viper; Saw-scaled viper.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100308
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Envenomation by scorpion in dog: case report J. Venom. Anim. Toxins incl. Trop. Dis.
Cardoso,M. J. L.; Sakate,M.; Ciampolini,P.; Moutinho,F. Q.; Cherubini,A. L..
A case admitted at the Small Animals Clinics Service, Veterinary Hospital, FMVZ - UNESP, in May, 1999 is described. A Brazilian Terrier dog, 3 years and 3 months old, weighing 1.7 kg was brought after 2 hours and a half from contact with a scorpion (Tityus bahiensis). The dog showed vocalization inserted with drowsiness. Physical examination showed slightly hyperemic mucous, pain, agressiveness, tachypnea, tachycardia, and discrete erythema on the right forelimb palmar face. An anesthetic block was performed around the stung area using 2% lidocaine hydrochloride without vasoconstrictor (10mL). The animal was asymptomatic, after 24 h treatment.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Scorpion; Dog; Envenomation; Poisoning; Tityus bahiensis.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992004000100008
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Envenomation by the madagascan colubrid snake, Ithycyphus miniatus J. Venom. Anim. Toxins incl. Trop. Dis.
Mori,A.; Mizuta,T..
We report two cases of envenomation by a Madagascan opisthoglyphous snake, Ithycyphus miniatus. In both cases, the snake bit the finger of a human who was preparing an experiment by tying a string around the snake body. Symptoms of the first case included temporal severe local pain and extensive bleeding. In the second case, severe pain accompanying obvious local swelling was caused and lasted for several hours. The present observations indicate that bite by I. miniatus potentially causes serious physiological effects in humans although the snake is basically calm and reluctant to bite.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Madagascar; Colubrid; Ithycyphus miniatus; Envenomation; Opisthoglyph; Duvernoy's glands.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300013
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Envenomation by the Malagasy colubrid snake Langaha madagascariensis J. Venom. Anim. Toxins incl. Trop. Dis.
D'Cruze,NC.
This report documents a case of envenomation by a Malagasy opisthoglyphous snake, Langaha madagascariensis. The snake bit the finger of a healthy adult man who was attempting to record its morphological measurements as part of a biodiversity survey which was being conducted in the extreme north of Madagascar. Symptoms of this case included severe local pain accompanied by observable swelling which lasted for several days. The present observations indicate that bite by L. madagascariensis potentially causes notable physiological effects in humans although the snake is generally calm and reluctant to bite unless provoked.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Madagascar; Colubrid; Langaha madagascariensis; Envenomation; Opisthoglyph; Duvernoy's glands.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000300014
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Envenomation caused by Latrodectus geometricus in São Paulo state, Brazil: a case report J. Venom. Anim. Toxins incl. Trop. Dis.
Almeida,Ramb; Ferreira Junior,RS; Chaves,CR; Barraviera,B.
Widow spiders (Latrodectus spp.), also known as "black widows", have a worldwide distribution and can cause latrodectism. To the best of our knowledge, in Brazil, only one case of Latrodectus geometricus (Koch, 1841) envenomation in a human has been reported. The aim of the present report is to describe a spider bite caused by Latrodectus geometricus in a patient who lives in Paranapanema, São Paulo state, Brazil.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Latrodectus geometricus; Envenomation; Latrodectism; Brown widow.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300016
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Envenomation caused by Rhopalurus amazonicus Lourenço, 1986 (Scorpiones, Buthidae) in Pará State, Brazil J. Venom. Anim. Toxins incl. Trop. Dis.
Fuentes-Silva,Deyanira; Santos Jr,Alfredo P; Oliveira,Joacir Stolarz.
Scorpions, mainly those belonging to the genus Tityus cause many deaths and injuries in Brazil, with tens of thousands of envenomations notified every year. However, injuries involving other scorpion species are scarcely registered. Among the sixteen species of the genus Rhopalurus, Thorell, 1876, described up to date, nine are found in this country, with only a confirmed case of human envenomation provoked by R. agamemnonKoch, 1839. The present case reports, for the first time, a case of scorpion sting in a human victim involving Rhopalurus amazonicus, endemic species of the west region of the Pará state, Amazon, Brazil. The symptoms of envenomation were local pain and paresthesia. This study contributes to develop the knowledge on venomous scorpions,...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Scorpion sting; Rhopalurus amazonicus; Venomous animals; Envenomation; Brazilian Amazon; Pará.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200509
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Epidemiological and clinical characteristics of scorpion stings in children in fez, Morocco J. Venom. Anim. Toxins incl. Trop. Dis.
Abourazzak,S; Achour,S; El Arqam,L; Atmani,S; Chaouki,S; Semlali,I; Soulaymani Bencheikh,R; Bouharrou,A; Hida,M.
Scorpion stings are a public health problem in Morocco, especially among children, who experience the most severe cases. Epidemiological and clinical findings on scorpion stings in Fez, Morocco, were evaluated in this investigation. Of 163 cases that required medical attention, 62.6% were male children. The mean age of patients was 4.8 ± 3.4 years. The mean time between stings and first medical attention was 3.36 ± 2.5 hours. Almost all cases occurred in the summer (94%) and extremities represented the most frequent sting sites (86.5%). Local pain, hyperemia, scarification, vomiting, sweating, restlessness, tachycardia and tachypnea were the observed clinical symptoms. Regarding severity, 55.2% of patients belonged to class III, followed by class II...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion sting; Clinical symptoms; Envenomation; Treatment; Children; Morocco.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200008
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Epidemiological profile of snakebites in Rio de Janeiro, Brazil, 2001-2006 J. Venom. Anim. Toxins incl. Trop. Dis.
Machado,C; Bochner,R; Fiszon,JT.
All snakebites registered in Rio de Janeiro state, Brazil, between 2001 and 2006 were analyzed. Of these, the snake species involved was identified in 2,431 cases, most of which were caused by Bothrops (2,347). Most victims were male (78.4%) and the age group most frequently attacked was between 20 and 39 years (38.4%). As for severity, 1,118 (45.9%) were classified as minor, 748 (30.7%) as moderate, and 209 (8.6%) as severe. Progression towards complete cure occurred in 1,567 patients; 39 had sequelae; three died; and clinical outcomes were not monitored in 822 cases. The time between bite and first medical attention was less than three hours in 74.6% of cases. Most occurred in municipalities with vast areas of preserved Atlantic Forest: Angra dos Reis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Snakebites; Envenomation; Snake bite epidemiology; Information systems.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000200012
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Epidemiology of envenomations by terrestrial venomous animals in Brazil based on case reporting: from obvious facts to contingencies J. Venom. Anim. Toxins incl. Trop. Dis.
Chippaux,Jean-Philippe.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Envenomation; Snakes; Scorpions; Spiders; Caterpillars; Africanized bees; Brazil; Epidemiology.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100319
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Epidemiology of snakebites in Kédougou region (eastern Senegal): comparison of various methods for assessment of incidence and mortality J. Venom. Anim. Toxins incl. Trop. Dis.
Lam,Absa; Camara,Bouna; Kane,Oumar; Diouf,Amadou; Chippaux,Jean-Philippe.
Abstract Background Although considered a public health issue in Senegal, the actual incidence and mortality from snakebite are not known. In the present study, an epidemiological survey was carried out in Kédougou region, southeastern Senegal, where envenomations, particularly by Echisocellatus, are frequent and severe. Methods Three sources of data were used: records from health centers and reports by health professionals; traditional healers; and household surveys. Results The annual incidence and mortality provided by health centers were 24.4 envenomations and 0.24 deaths per 100,000 population, respectively. The annual incidence recorded by traditional healers was 250 bites per 100,000 inhabitants, but the number of deaths was unknown. Finally,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epidemiology; Snakebite; Envenomation; Senegal; Incidence.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100307
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Ethnomedicinal plants used for snakebite treatments in Ethiopia: a comprehensive overview J. Venom. Anim. Toxins incl. Trop. Dis.
Yirgu,Abraham; Chippaux,Jean-Philippe.
Abstract Traditional medicine plays an important role in the daily lives of people living in rural parts of Ethiopia. Despite the fact that Ethiopia has a long history of using traditional medicinal plants as an alternative medicine source, there is no checklist compiling these plants used for snakebite treatment. This review collected and compiled available knowledge on and practical usage of such plants in the country. A literature review on medicinal plants used to treat snakebites was conducted from 67 journal articles, PhD dissertation and MSc theses available online. Data that summarize scientific and folk names, administration methods, plant portion used for treatment and method of preparation of recipes were organized and analyzed based on citation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethnobotany; Medicinal plant; Traditional treatment; Snakebite; Envenomation; Sub-Saharan Africa; Ethiopia.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100205
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Fatal neurotoxic envenomation following the bite of a greater black krait (Bungarus niger) in Nepal: a case report J. Venom. Anim. Toxins incl. Trop. Dis.
Pandey,Deb Prasad; Sharma,Sanjib Kumar; Alirol,Emilie; Chappuis,François; Kuch,Ulrich.
Abstract Background Neurotoxic envenomation following bites by kraits (Bungarus species) is a leading cause of snakebite mortality in South Asia. Over a long time, this had been attributed only to one species, the common krait (Bungarus caeruleus). However, recent research has provided increasing evidence of the involvement of several krait species. Here, we report a fatal case of neurotoxic envenomation following the bite of a greater black krait (Bungarus niger) in Nepal. Case presentation A 33-year-old man was bitten in the outdoor corridor of his home in the eastern hills of Ilam district while handling a snake he thought to be non-venomous. He subsequently developed severe abdominal pain, frequent vomiting, and signs of neurotoxic envenomation...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Bungarus niger; Neurotoxicity; Krait; Envenomation; Antivenom; Snakebite.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100503
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Immediate radical fang mark ablation may allow treatment of japanese viper bite without antivenom J. Venom. Anim. Toxins incl. Trop. Dis.
Fujioka,M; Oka,K; Kitamura,R; Yakabe,A; Ito,M.
Administration of antivenom is currently the standard treatment for snake envenomation. However, it can sometimes cause anaphylactic reactions including urticaria, bronchospasm and hypotension. Furthermore, it may also provoke life-threatening complications, even though the mortality rate is less than 1%. In this study, we present a new treatment - immediate radical fang mark ablation - that was successfully performed on five victims of Japanese viper bites without antivenom use. In these five victims of venomous snakebites, surgical debridement was immediately performed. Two patients received a free-skin graft to resurface their wounds while three of them healed conservatively (i.e. by ointment treatment without surgery). After treatment, all patients...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ablation; Viper bite; Antivenom; Fang mark; Envenomation.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100016
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In vivo and in vitro effects of scorpion venoms in Turkey: a mini-review J. Venom. Anim. Toxins incl. Trop. Dis.
Adiguzel,S.
Scorpion stings constitute a common type of accident in Turkey due to the geographic location, climate and socioeconomic structure of this country. Moreover, envenomation cases are considered a public health problem throughout Turkey. Based on data in the literature, the main clinical features of scorpion envenomations are defined as systemic manifestations including sweating, hypertension and vomiting, and among prominent causes of death are cardiorespiratory manifestations, toxic myocarditis and pulmonary edema. The most important health-threatening scorpions found in Turkey are: Androctonus crassicauda, Leiurus quinquestriatus, Mesobuthus gibbosus and Mesobuthus eupeus, all of which belong to the Buthidae family. This study indicates that there is no...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpions; Venom; Envenomation; In vivo and in vitro effects; Turkey.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200004
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Potential envenomation by the aglyphous pseudoxyrhophiine snake Leioheterodon madagascariensis and description of its dentition J. Venom. Anim. Toxins incl. Trop. Dis.
Razafimahatratra,Bertrand; Wang,Cynthia; Mori,Akira; Glaw,Frank.
Abstract We report on a case of potential envenomation caused by multiple bites by the aglyphous opisthodont snake Leioheterodon madagascariensis in the left thumb of a healthy adult man, which is among the most serious snakebites hitherto reported from Madagascar. The adult snake (total length > 1 meter) was unusually aggressive before and during capture. The symptoms included extensive bleeding, severe local pain, and substantial swelling of the hand and the distal part of the lower arm. The swelling disappeared entirely after five days, but pain in the thumb (when moved) was recognizable even longer. Although L. madagascariensis is widespread and common in anthropogenic habitats in eastern and western Madagascar, this case report seems to be the...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Madagascar; Lamprophiidae; Pseudoxyrhophiinae; Leioheterodon madagascariensis; Envenomation; Dentition; Microcomputed tomography.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100413
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Retrospective study on the incidence of envenomation and accessibility to antivenom in Burkina Faso J. Venom. Anim. Toxins incl. Trop. Dis.
Gampini,Sandrine; Nassouri,Sonia; and,Jean-Philippe Chippaux; Semde,Rasmané.
Abstract Background Snakebite is a common neglected public health issue, especially in poor rural areas of sub-Saharan Africa, Asia and Latin America. Passive immunotherapy with safe and effective antivenom is the only approved treatment for it. This study aimed to determine the incidence of snakebites, and to assess the availability and accessibility of antivenoms, from 2010 to 2014, in Burkina Faso. Methods The assessment of snakebite cases managed in all health facilities from 2010 to 2014 was performed from the Statistical Yearbook of the Ministry of Health. Antivenom consumption data were collected from the drug wholesalers established in Burkina Faso. Results Snakebites are among the five leading causes of consultations in health districts....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Envenomation; Snakebite; Antivenom; Burkina Faso.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100309
Registros recuperados: 29
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